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Fig. 3 | Acta Veterinaria Scandinavica

Fig. 3

From: Exposure to benzylpenicillin after different dosage regimens in growing pigs

Fig. 3

Total plasma concentration–time courses of benzylpenicillin in pigs after repeated intramuscular dosing of different formulations. Total plasma concentration–time courses of benzylpenicillin after repeated intramuscular dosing of different formulations of the drug in pigs experimentally inoculated with Actinobacillus pleuropneumoniae serotype 2. Each line represents an individual pig. Discontinuation of the concentration–time courses means that no samples were collected within one dose-interval. Plot a 30 mg/kg Ultrapen qd to twelve pigs for 3 days and to six of these for an additional 2 days. Plot b A single dose of 30 mg/kg Ethacilin followed by repeated administration of 30 mg/kg Ultrapen qd for 3 days starting at 12 h in six pigs. Plot c 30 mg/kg Ethacilin bid for 5 days to six pigs. Plot d an initial dose of 60 mg/kg Ultrapen followed by 30 mg/kg qd for 2 days starting at 24 h to six pigs. The horizontal lines denote the approximate total plasma concentration of benzylpenicillin necessary to exceed MIC of 500 µg/L for A. pleuropneumoniae, considering a protein binding of 45%

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