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Table 3 Diagnostic accuracy of blood sucrose for diagnosis of EGUS using traditional and Bayesian latent class analyses in 45 foals evaluated pre and post weaning

From: Diagnostic accuracy of blood sucrose as a screening test for equine gastric ulcer syndrome (EGUS) in weanling foals

Lesion type Test Parameter Gold standarda Bayesian LCb
Estimate % (95% CI) Estimate % (95% PI)
GL Sucrose 45 Sensitivity 89 (78, 95) 89 (77, 97)
Specificity 65 (47, 79) 83 (65, 95)
Sucrose 90 Sensitivity 84 (72, 92) 81 (69, 91)
Specificity 71 (53, 84) 95 (80, 100)
Endoscopy Sensitivity NA 81 (70, 90)
Specificity NA 99 (95, 100)
GDL Sucrose 45 Sensitivity 95 (79, 99) 97 (90, 100)
Specificity 47 (34, 60) 87 (69, 98)
Sucrose 90 Sensitivity 90 (73, 97) 91 (80, 99)
Specificity 55 (42, 67) 97 (83, 100)
Endoscopy Sensitivity NA 47 (36, 59)
Specificity NA 99 (95, 100)
SQL Sucrose 45 Sensitivity 89 (77, 96) 90 (78, 98)
Specificity 55 (39, 70) 77 (55, 91)
Sucrose 90 Sensitivity 87 (74, 94) 84 (72, 94)
Specificity 64 (48, 78) 94 (76, 100)
Endoscopy Sensitivity NA 75 (62, 87)
Specificity NA 99 (94, 100)
CSL Sucrose 45 Sensitivity 94 (80, 98) 95 (88, 99)
Specificity 52 (38, 66) 89 (71, 99)
Sucrose 90 Sensitivity 90 (75, 96) 89 (79, 97)
Specificity 58 (44, 71) 98 (85, 100)
Endoscopy Sensitivity NA 60 (48, 71)
Specificity NA 99 (96, 100)
  1. CI confidence interval, PI probability interval; Bayesian analog of the confidence interval. NA not able to calculate since endoscopy is considered the gold standard reference test
  2. GL gastric lesion, GDL glandular lesion, SQL squamous lesion, CSL clinically significant lesion
  3. aCalculated relative to direct observation of lesions via endoscopy as the gold standard
  4. bBased on Bayesian latent class analysis with sucrose tests evaluated at the 24 µmol/L cutoff and endoscopy assumed to be an imperfect test