Table 2 Homology of the amino acid sequences between the canine and human or bovine cytokines targeted by the evaluated anti-human or anti-bovine mAbs
Species | Cytokines | Homology to canines (%) |
|---|---|---|
Human | IL-1-α | 70 |
IL-1-β | 78 | |
IL-2 | 74 | |
IL-4 | 49 | |
IL-5 | 65 | |
IL-6 | 59 | |
IL-8 | 77 | |
IL-10 | 78 | |
IL-12 | 84 | |
IL-13 | 72 | |
IL-17A | 81 | |
IFN-γ | 85 | |
TNF-α | 91 | |
TGF-β | 96 | |
Bovine | IL-4 | 65 |
IFN-γ | 76 |