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Acute, Oral Toxicity to Laboratory Animals of Fenthion (O-O-Dimethyl-O-(3-Methyl-4-Methyl-Mercapto-Phenyl)-Thiophosphate) in Different Formulations

Die akute, orale Toxizität verschiedener Emulsionen des Stoffes Fenthion (O-O-Dimethyl-O-(3-Methyl-4-Methylmercapto-Phenyl)-Thiophosphat) gegenüber Ratten und Mäusen

Den akutte, orale toksisitet for rotte og mus av fenthion (O,O-dimethyl-O-(3-methyl-4-methylmercapto-fenyl)-thiofosfat) i forskjellige formuleringer

Acta Veterinaria Scandinavica volume 6, pages 112–117 (1965)Cite this article

Summary

The acute, oral toxicity of fenthion (O,O-dimethyl-O-(3-methyl-4-methylmercapto-phenyl)thiophosphate) in different formulations emulgated in water was studied. For male, white rats the approximate values for LD50 found varied from 340 to 560 mg per kg, technical fenthion in commercial products being more toxic than the chemically pure compound. Fenthion in the commercial preparation Lebaycid was more toxic for male, white mice (LD50 approx. 125 mg per kg) than for rats.

Zusammenfassung

Die akute, orale Toxizität von Fenthion (O,O-Dimethyl-O-(3-Methyl-4-Methylmercapto-Phenyl)Thiophosphat) in verschiedenen in Wasser emulgierten Formen ist untersucht worden. Die annähernden Werte für LD50 variierten in Versuchen mit weissen Ratten (♂) von 340 bis 560 mg pro kg. Technisches Fenthion in commerziellen Produkten erwies sich giftiger als der chemisch reine Stoff. Fenthion in dem commerziellen Präparat Lebaycid zeigte grössere toxische Wirkung gegenüber weissen Mäusen (♂) (LD50 annähernd 125 mg pro kg) als bei Ratten.

Sammanfattning

Undersøkelsene er utført med fire forskjellige fenthionformuleringer emulgert i vann. De tilnærmede LD50-verdier for voksne, hvite hanrotter varierte mellom 340–560 mg/kg, idet teknisk fenthion i handelspreparater var noe mer giftig enn det kjemisk rene stoff. Fenthion i form av handelspreparatet Lebaycid var mer giftig for hvite hanmus (LD50 ca. 125 mg/kg) enn for rotter.

References

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  1. Department of Pharmacology and Toxicology, Veterinary College of Norway, Oslo, Norway

    Johan Sakshaug

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  1. Johan Sakshaug
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Sakshaug, J. Acute, Oral Toxicity to Laboratory Animals of Fenthion (O-O-Dimethyl-O-(3-Methyl-4-Methyl-Mercapto-Phenyl)-Thiophosphate) in Different Formulations. Acta Vet Scand 6, 112–117 (1965). https://0-doi-org.brum.beds.ac.uk/10.1186/BF03547071

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  • DOI: https://0-doi-org.brum.beds.ac.uk/10.1186/BF03547071

Acta Veterinaria Scandinavica

ISSN: 1751-0147