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Table 1 Pharmacokinetic variables calculated for doxycycline (10 mg/kg) in dogs through compartmental analysis, after either the IV, PO and SC administration of an aqueous solution, a preparation as tablet or the experimental long acting preparation, respectively

From: Pharmacokinetics of an injectable long-acting formulation of doxycycline hyclate in dogs

 

Doxycycline IV

Doxycycline PO

Doxycycline SC

Mean ± SE

Mean ± SE

Mean ± SE

AUC0-∞ (μg·h/mL)

97.34 ± 7.45a

72.89 ± 6.3b

194.18 ± 12.72c

AUCt (μg·h/mL)

109.66 ± 8.56a

70.33 ± 6.23b

129.70 ± 9.56c

AUMCt (μg·h2/mL)

909.64 ±23.82a

820.11 ± 18.63b

10453.52 ± 135.78c

RT (h)

10.10 ± 1.12a

10.22 ± 2.21a

166.63 ± 5.58b

ab (h)

-

1.49 ± 0.07

-

el (h-1)

2.87 ± 0.02a

5.59 ± 0.03b

45.21 ± 0.74c

A (h-1)

14.99 ± 0.11a

-

2.16 ± 0.03b

B (h-1)

8.50 ± 0.07a

-

0.86 ± 0.01b

α (h-1)

2.49 ± 0.02a

-

0.07 ± 0.004b

β (h-1)

0.09 ± 0.003a

-

0.005 ± 0.001

T½α (h-1)

0.28 ± 0.01

-

9.30 ± 0.36 b

T½β (h-1)

7.44 ± 0.06 a

-

133.61 ± 6.32 b

Vdc (L/kg)

6.37 ± 0.76

-

-

Vdarea (L/kg)

1.49 ± 0.27

-

-

Vdss (L/kg)

11.34 ± 1.24

-

-

Cs0 (μg/mL)

23.54 ± 4.32

-

-

Cmax (μg/mL)

-

5.58 ± 0.5a

2.8 ± 0.3b

Tmax (h)

-

3.88 ± 0.4a

2.11 ± 0.12b

ClB (mL/kg · h-1)

134 ± 8

-

-

F (%)*

-

74.88

199.48

  1. a,b,c,dThe values within a row with no common superscript differ significantly (P < 0.05).
  2. AUC0-∞ = area under the concentration-time curve from zero up to ∞ with extrapolation of the terminal phase; AUMC = area under the first moment of the concentration-time curve; AUCt = area under the concentration-time curve calculated by the trapezoidal method; AUMCt = area under the first moment of the concentration-time curve calculated by the trapezoidal method; RT = retention time; K½el = elimination half rate constant from the central compartment; K½ab = absorption half rate constant from the central compartment; A, B, = zero time intercepts of the distribution and post-distribution phases; α and β = hybrid rate constants for the distribution and elimination phases, respectively; T½β = half-life of the elimination; Vdc= volume of the central compartment; Vdarea= Volume calculated by the area method; Vdss = apparent volume of distribution at steady-state; Cs0 = calculated maximum plasma concentration at zero time; Cmax = calculated maximum plasma concentration; Tmax = time of maximum plasma concentration; ClB = clearance from the body; F = bioavailability.