| Doxycycline IV | Doxycycline PO | Doxycycline SC |
---|
Mean ± SE | Mean ± SE | Mean ± SE |
---|
AUC0-∞ (μg·h/mL) | 97.34 ± 7.45a | 72.89 ± 6.3b | 194.18 ± 12.72c |
AUCt (μg·h/mL) | 109.66 ± 8.56a | 70.33 ± 6.23b | 129.70 ± 9.56c |
AUMCt (μg·h2/mL) | 909.64 ±23.82a | 820.11 ± 18.63b | 10453.52 ± 135.78c |
RT (h) | 10.10 ± 1.12a | 10.22 ± 2.21a | 166.63 ± 5.58b |
K½ab (h) | - | 1.49 ± 0.07 |
-
|
K½el (h-1) | 2.87 ± 0.02a | 5.59 ± 0.03b | 45.21 ± 0.74c |
A (h-1) | 14.99 ± 0.11a | - | 2.16 ± 0.03b |
B (h-1) | 8.50 ± 0.07a | - | 0.86 ± 0.01b |
α (h-1) | 2.49 ± 0.02a | - | 0.07 ± 0.004b |
β (h-1) | 0.09 ± 0.003a | - | 0.005 ± 0.001 |
T½α (h-1) | 0.28 ± 0.01 | - | 9.30 ± 0.36 b |
T½β (h-1) | 7.44 ± 0.06 a | - | 133.61 ± 6.32 b |
Vdc (L/kg) | 6.37 ± 0.76 | - |
-
|
Vdarea (L/kg) | 1.49 ± 0.27 | - |
-
|
Vdss (L/kg) | 11.34 ± 1.24 | - |
-
|
Cs0 (μg/mL) | 23.54 ± 4.32 | - | - |
Cmax (μg/mL) | - | 5.58 ± 0.5a | 2.8 ± 0.3b |
Tmax (h) | - | 3.88 ± 0.4a | 2.11 ± 0.12b |
ClB (mL/kg · h-1) | 134 ± 8 | - | - |
F (%)* | - | 74.88 | 199.48 |
- a,b,c,dThe values within a row with no common superscript differ significantly (P < 0.05).
- AUC0-∞ = area under the concentration-time curve from zero up to ∞ with extrapolation of the terminal phase; AUMC = area under the first moment of the concentration-time curve; AUCt = area under the concentration-time curve calculated by the trapezoidal method; AUMCt = area under the first moment of the concentration-time curve calculated by the trapezoidal method; RT = retention time; K½el = elimination half rate constant from the central compartment; K½ab = absorption half rate constant from the central compartment; A, B, = zero time intercepts of the distribution and post-distribution phases; α and β = hybrid rate constants for the distribution and elimination phases, respectively; T½β = half-life of the elimination; Vdc= volume of the central compartment; Vdarea= Volume calculated by the area method; Vdss = apparent volume of distribution at steady-state; Cs0 = calculated maximum plasma concentration at zero time; Cmax = calculated maximum plasma concentration; Tmax = time of maximum plasma concentration; ClB = clearance from the body; F = bioavailability.