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Table 1 Results from interferon gamma immunoassays (IFN-γ), and serological, pathological and bacteriological examination of 45 animals in a dairy herd

From: Description of the Infection Status in a Norwegian Cattle Herd Naturally Infected by Mycobacterium avium subsp. paratuberculosis

Age (Years) IFNγ1 Serology2 Pathology3 Bacteriology faeces/organs No of animals
9 + - - -/- 1
  nd ++ Granulomatous enteritis Acid fast rods M. a. paratuberculosis/M. a. paratuberculosis 14
  nd ++ - -/- 14
5 + ++ - -/- 2
  - ++ Granulomatous enteritis Acid fast rods -/- 1
  - +/- - -/- 1
  - - Granulomatous enteritis Acid fast rods -/M. a. paratuberculosis 1
  nd - - -/- 1
4 ++ ++ Granulomatous enteritis Acid fast rods Mycobacterium sp/- 1
  ++ ++ - -/- 1
  ++ - - -/- 2
  + - - -/- 1
  - ++ - -/- 1
  - - - -/- 2
3 - - - -/- 1
  nd - - -/- 1
2.5 ++ +/- - -/- 1
  + +/- - -/- 1
  + - - -/- 2
  - ++ - -/- 1
  - - - -/- 1
1.5 ++ +/- - -/- 1
  ++ - - Mycobacterium sp/- 1
  ++ - - -/- 1
  + - - -/- 1
  - - - -/- 1
1.0 ++ ++ - -/- 1
  ++ - - -/- 1
  + - - -/- 2
  - +/- - -/- 1
  - - - -/- 4
0.5 + - - -/- 2
  - - - -/- 4
  1. 1 IFN-γgositive (++): OD ≥ 0.4; Weakly positive (+): OD ≥ 0.1 and <0.4; Negative (-): OD < 0.1.
  2. 2 ELISA Positive (++): S/P ≥ 0.3; Doubtful (+/-): S/P ≥ 0.15 and <0.3; Negative (-): S/P < 0.15.
  3. 3 Granulomatous enteritis without identification of acid-fast rods was considered a negative finding having aetiology other than infection with Mycobacterium avium subsp. paratuberculosis. Occasional small inflammatory foci without identification of acid-fast rods were seen. In over 50% of these lesions, the inflammatory cells contained pigment or foreign material such as coccidia and plant material.
  4. 4 Animals that underwent full post-mortem examination.
  5. nd = Not done