Table 1 Pharmacokinetic parameters (median (range)) in plasma following flunixin meglumine (2.2 mg/kg) given intravenously, intramuscularly and orally to 6 Norwegian dairy goats.

AUC

h/μg/ml

21

(14–36)

16

(14–19)

12

(7.5–17)

CL

ml/h/kg

110

(60–160)

-

-

Vd_ss

l/kg

0.35

(0.23–0.41)

-

-

λ

l/h

0.19

(0.14–0.35)

0.20

(0.10–0.27)

0.16

(0.12–0.20)

Vd_λ

l/kg

0.5

(0.4–0.8)

-

-

MRT

h

3.1

(2.1–5.9)

4.2

(3.5–4.5)

7.7

(6.0–9.3)

t1/2

h

3.6

(2.0–5.1)

3.4

(2.6–7.1)

4.2

(3.4–6.0)

C_max1

μg/ml

-

6.1

(3.3–7.4)

1.2

(0.8–2.0)

C_max2

μg/ml

-

-

1.3

(0.8–1.8)

T_max1

h

-

0.37

(0.25–0.75)

0.37

(0.25–1.0)

T_max2

h

-

-

3.5

(2.5–5)

F

%

-

79

(53–112)

58

(35–120)